Publications

2017

Renfer E, Technau U. Meganuclease-assisted generation of stable transgenics in the sea anemone Nematostella vectensis. (2017) Nature Protocols DOI: nprot.2017.075, in press

 

Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R. (2017) Back to the Basics: Cnidarians Start to Fire. Trends Neurosci. 2017 Feb;40(2):92-105. Review.

 

2016

Moran, Y. Agron, M., Praher, D., Technau, U. (2017). The evolutionary origin of plant and animal miRNAs. Nature Ecology and Evolution, in press.

 

Rentzsch F, Technau U. Genomics and development of Nematostella vectensis and other anthozoans. Curr Opin Genet Dev. 2016 Jun 16;39:63-70. doi: 10.1016/j.gde.2016.05.024. Review.

 

Kraus Y, Aman A, Technau U, Genikhovich G. Pre-bilaterian origin of the blastoporal axial organizer. Nature Commun. 2016 May 27;7:11694. doi: 10.1038/ncomms11694.

 

2015 

Kelava I, Rentzsch F, Technau U. (2015) Evolution of eumetazoan nervous systems: insights from cnidarians. Philos Trans R Soc Lond B Biol Sci. 2015 Dec 19;370(1684). pii: 20150065. doi: 10.1098/rstb.2015.0065. Review.

 

Technau U, Schwaiger M. (2015) Recent advances in genomics and transcriptomics of cnidarians. Mar Genomics. 2015 Sep 25. pii: S1874-7787(15)30030-1. (review)

 

Kraus JE, Fredman D, Wang W, Khalturin K, Technau U. (2015) Adoption of conserved developmental genes in development and origin of the medusa body plan. Evodevo. 2015 May 29;6:23. doi: 10.1186/s13227-015-0017-3. eCollection 2015.

 

Mortzfeld BM, Urbanski S, Reitzel AM, Künzel S, Technau U, Fraune S. (2015) Response of bacterial colonization in Nematostella vectensis to development, environment and biogeography. Environ Microbiol. 2015 Jun 1. doi: 10.1111/1462-2920.12926.

 

Ostrovsky AN, Lidgard S, Gordon DP, Schwaha T, Genikhovich G, Ereskovsky AV. (2015) Matrotrophy and placentation in invertebrates: a new paradigm. Biol Rev Camb Philos Soc. 2015 Apr 29. doi: 10.1111/brv.12189.

 

Technau, U., Genikhovich, G.  and Kraus, J.E.M. (2015). Cnidaria. In: Evolutionary Developmental Biology of Invertebrates. Vol. 1, pp. 115-163. Editor: A. Wanninger. Springer, New York.

 

Genikhovich G, Fried P, Prünster MM, Schinko JB, Gilles AF, Fredman D, Meier K, Iber D, Technau U (2015) Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints.Cell Rep. 2015 Mar 11

 

Tarrant AM, Gilmore TD, Reitzel AM, Levy O, Technau U, Martindale MQ. (2015) Current directions and future perspectives from the third Nematostella research conference. Zoology (Jena). 2015 Apr;118(2):135-40

 

2014

Bosch TC, Adamska M, Augustin R, Domazet-Loso T, Foret S, Fraune S, Funayama N, Grasis J, Hamada M, Hatta M, Hobmayer B, Kawai K, Klimovich A, Manuel M, Shinzato C, Technau U, Yum S, Miller DJ (2014) How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans.Bioessays. 2014 Dec;36(12):1185-94

 

Jahnel SM, Walzl M, Technau U (2014) Development and epithelial organisation of muscle cells in the sea anemone Nematostella vectensis. Front Zool. 2014 Jun 18;11:44

 

Schwaiger M, Schönauer A, Rendeiro AF, Pribitzer C, Schauer A, Gilles AF, Schinko JB, Renfer E, Fredman D, Technau U (2014) Evolutionary conservation of the eumetazoan gene regulatory landscape. Genome Res. 2014 Mar 18. [Epub ahead of print]

 

Moran Y, Fredman D, Praher D, Li XZ, Wee LM, Rentzsch F, Zamore PD, Technau U, Seitz H (2014) Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res. 2014 Mar 18. [Epub ahead of print]

 

Hudry B, Thomas-Chollier M, Volovik Y, Duffraisse M, Dard A, Frank D, Technau U, Merabet S (2014) Molecular insights into the origin of the Hox-TALE patterning system. Elife. 2014 Mar 18;3:e01939. doi: 10.7554/eLife.01939.

 

2013

Moran Y, Praher D, Fredman D, Technau U (2013) The evolution of microRNA pathway protein components in Cnidaria. Mol Biol Evol. 2013 Dec;30(12):2541-52

 

Technau U, Weis VM (2013) EvoDevo meets ecology: the Ninth Okazaki Biology Conference on Marine Biology. Evodevo. 2013 Jun 24;4(1):18

 

Sinigaglia C, Busengdal H, Leclère L, Technau U, Rentzsch F (2013) The bilaterian head patterning gene six3/6 controls aboral domain development in a cnidarian. PLoS Biol. 2013 Feb;11(2):e1001488.

 

2012

Moran Y, Praher D, Schlesinger A, Ayalon A, Tal Y, Technau U (2012) Analysis of Soluble Protein Contents from the Nematocysts of a Model Sea Anemone Sheds Light on Venom Evolution. Mar Biotechnol (NY). 2012 Nov 15

 

Gur Barzilai M, Reitzel AM, Kraus JE, Gordon D, Technau U, Gurevitz M, Moran Y (2012) Convergent evolution of sodium ion selectivity in metazoan neuronal signaling. Cell Rep. 2012 Aug 30;2(2):242-8

 

Steinmetz PR, Kraus JE, Larroux C, Hammel JU, Amon-Hassenzahl A, Houliston E, Wörheide G, Nickel M, Degnan BM, Technau U (2012) Independent evolution of striated muscles in cnidarians and bilaterians. Nature. 2012 Jun 27;487(7406):231-4

 

Moran Y, Fredman D, Szczesny P, Grynberg M, Technau U (2012) Recurrent Horizontal Transfer of Bacterial Toxin Genes to Eukaryotes. Mol Biol Evol. 2012 Apr 4

 

Nakanishi N, Renfer E, Technau U, Rentzsch F (2012) Nervous systems of the sea anemone Nematostella vectensis are generated by ectoderm and endoderm and shaped by distinct mechanisms. Development. 2012 Jan;139(2):347-57

 

2011

Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Ozbek S, Technau U, Gurevitz M (2011) Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc Biol Sci. 2011 Nov 2.

 

Genikhovich G, Technau U (2011) Complex functions of Mef2 splice variants in the differentiation of endoderm and of a neuronal cell type in a sea anemone. Development. 2011 Nov;138(22):4911-9

 

Irimia M, Denuc A, Burguera D, Somorjai I, Martín-Durán JM, Genikhovich G, Jimenez-Delgado S, Technau U, Roy SW, Marfany G, Garcia-Fernàndez J (2011) Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5319-24. Epub 2011 Mar 9

 

Technau U, Steele RE (2011) Evolutionary crossroads in developmental biology: Cnidaria. Development. 2011 Apr;138(8):1447-58. Epub 2011 Mar 9. Review

 

2010

Steele RE, David CN, Technau U (2010) A genomic view of 500 million years of cnidarian evolution. Trends Genet. 2010 Nov 1. 

 

Raible F, Steinmetz PRH (2010). Metazoan complexity. In: Introduction to Marine Genomics. Edited by Cock JM, Tessmar-Raible K, Boyen C., Viard F. Springer Dordrecht Heidelberg London New York.

 

Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam D, Disbennett K, Pfannkoch C, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Bertulat B, Guder C, Nakamura Y, Ozbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz PR, Zhang X, Aufschnaiter R, Eder MK, Gorny AK, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TC, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE (2010) The dynamic genome of Hydra. Nature. 2010 Mar 25;464(7288):592-6

 

Miller DJ, Technau U. (2010) Understanding the evolution of multicellularity: insights from basal metazoans. Bioessays. 2010 Feb;32(2):175-8

 

Renfer E, Amon-Hassenzahl A, Steinmetz PRH, Technau U (2010) A muscle-specific transgenic reporter line of the sea anemone Nematostella vectensis. PNAS 2010 Jan 5; 107:104-108

 

Genikhovich G, Technau U (2010) The starlet sea anemone Nematostella vectensis: an anthozoan model organism for studies in comparative genomics and functional evolutionary developmental biology. CSH Protoc. 2009 Sep;2009(9):pdb.emo129 

 

Genikhovich G, Technau U (2010) Bromodeoxyuridine labeling of S-phase nuclei in the starlet sea anemone Nematostella vectensis. CSH Protoc. 2009 Sep;2009(9):pdb.prot5284

 

Genikhovich G, Technau U (2010) Anti-acetylated tubulin antibody staining and phalloidin staining in the starlet sea anemone Nematostella vectensis. CSH Protoc. 2009 Sep;2009(9):pdb.prot5283

 

Genikhovich G, Technau U (2010) In situ hybridization of starlet sea anemone (Nematostella vectensis) embryos, larvae, and polyps. CSH Protoc. 2009 Sep;2009(9):pdb.prot5282

 

Genikhovich G, Technau U (2010) Induction of spawning in the starlet sea anemone Nematostella vectensis, in vitro fertilization of gametes, and dejellying of zygotes. CSH Protoc. 2009 Sep;2009(9):pdb.prot5281

 

2009

Saina M, Genikhovich G, Renfer E, Technau U (2009). BMPs and Chordin regulate patterning of the directive axis in a sea anemone. PNAS 2009 Nov 3; 106 (44): 18592-18597

 

Saina M, Technau U (2009). Characterization of myostatin/gdf8/11 in the starlet sea anemone Nematostella vectensis. J Exp Zool B Mol Dev Evol. 2009 Jun 16;312B(7):780-788

 

Egger B, Steinke D, Tarui H, De Mulder K, Arendt D, Borgonie G, Funayama N, Gschwentner R, Hartenstein V, Hobmayer B, Hooge M, Hrouda M, Ishida S, Kobayashi C, Kuales G, Nishimura O, Pfister D, Rieger R, Salvenmoser W, Smith J, Technau U, Tyler S, Agata K, Salzburger W, Ladurner P. (2009). To be or not to be a flatworm: the acoel controversy. PLoS ONE 4(5):e5502. 

 

Feta A, Do AT, Rentzsch F, Technau U, Kusche-Gullberg M (2008) Molecular analysis of heparan sulphate biosynthetic enzyme machinery and characterization of heparan sulphate structure in Nematostella vectensis. Biochem J. 2009 Jan 26

 

Yin Y, Bangs F, Paton IR, Prescott A, James J, Davey MG, Whitley P, Genikhovich G, Technau U, Burt DW, Tickle C (2008). The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development. 2009 Feb;136(4):655-64.

 

2008

Shinzato C, Iguchi A, Hayward DC, Technau U, Ball EE, Miller DJ (2008). Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa. BMC Evol Biol. 2008 Nov 12;8:311

 

Technau, U (2008). Evolutionary biology: Small regulatory RNAs pitch in. Nature, 455 (1184 - 1185)

 

Rentzsch F, Fritzenwanker JH, Scholz CB, Technau U (2008). FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis. Development, 135(10):1761-9.

 

2007

Bielen H, Oberleitner S, Marcellini S, Gee L, Lemaire P, Bode HR, Rupp R and Technau U (2007). Divergent functions of two ancient Hydra Brachyury paralogs suggest specific roles for their activation domains in tissue fate inductions. Development, 23(4187-97).

 

Kraus Y, Fritzenwanker J, Genikhovich G, Technau U (2007). The blastoporal organiser of a sea anemone. Curr Biol. 7(20):R874-6.

 

Fritzenwanker J, Genikhovich G, Kraus Y, Technau U (2007). Early development and axis specification in the sea anemone Nematostella vectensis. Dev Biol. 310(2):264-79.

 

Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A, Terry A, Shapiro H, Lindquist E, Kapitonov V, Jurka J, Genikhovich G, Grigoriev I, Lucas S, Steele R, Finnerty J, Technau U, Martindale M, Rokhasr D (2007). Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization. Science, 317(86-94).

 

2006

Chourrout D, Delsuc F, Chourrout P, Edvardsen RB, Rentzsch F, Renfer E, Jensen MF, Zhu B, de Jong P, Steeele RE, Technau U (2006). Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements. Nature, 442(7103):684-7.

 

Kraus Y and Technau U (2006). Gastrulation in the sea anemone Nematostella vectensis occurs by invagination and immigration: an ultrastructural study. Dev Genes Evol. (216): 119-132.

 

2005

Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, Schmidt HA, Technau U, von Haeseler A, Hobmayer B, Martindale MQ and Holstein TW (2005). Unexpected complexity of the Wnt gene family in a sea anemone. Nature 433:156-160.

 

Miller DJ, Ball EE and Technau U (2005). Cnidarians and ancestral genetic complexity in the animal kingdom. Trends Genet. (review) 21(10):536-9.

 

Rentzsch F, Anton R, Saina M, Hammerschmidt M, Holstein TW and Technau U. (2006). Asymmetric expression of BMP antagonists in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning. Dev Biol., 296:375-87.

 

Technau U, Rudd S, Maxwell P, Gordon PMK, Saina M, Grasso LC, Hayward DC, Sensen CW, Holstein TW, Ball EE, Miller DJ (2005). Maintenance of ancestral genetic complexity and non-metazoan genes in two basal cnidarians. Trends Genet. 21(12):633-9.

 

2004

Fritzenwanker JH, Saina M and Technau U (2004). Analysis of forkhead and snail expression reveals epithelial-mesenchymal transitions during gastrulation and metamorphosis in Nematostella vectensis. Dev Biol. 275:389-402.

 

Lindgens D, Holstein TW and Technau U (2004). Hyzic, the Hydra homolog of the zic/odd-paired gene, is involved in the early specification of the sensory nematocytes. Development 131:191-201.

 

Technau U, Hobmayer B, Rentzsch F and Holstein TW (2004). Molecular and cellular analysis of de novo pattern formation in Hydra. Function and Regulation of Cellular Systems: Experiments and Models 309-321.

 

2003

Marcellini S, Technau U, Smith JC and Lemaire P (2003). Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. Dev Biol. 260:352-361.

 

Scholz C and Technau U (2003). The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa). Dev Genes Evol. 212:563-70.

 

Technau U and Scholz C (2003). Origin and evolution of endoderm and mesoderm. Int J Dev Biol. 47:531-539.

 

Technau U, Miller M, Bridge D and Steele R (2003). Arrested apoptosis of nurse cells during Hydra oogenesis and embryogenesis. Dev Biol. 260:191-206.

 

2002

Fritzenwanker J and Technau U (2002). Induction of gametogenesis in the basal cnidarian Nematostella vectensis(Anthozoa). Dev Genes Evol. 212:99-103.

 

2001

Arendt D, Technau U and Wittbrodt J (2001). Evolution of the bilaterian larval foregut. Nature 409:81-85.

 

Technau U (2001). Brachyury, the blastopore and the evolution of the mesoderm. Bioessays 23:788-94.

 

2000

Technau U, Cramer von Laue C, Rentzsch F, Luft S, Hobmayer B, Bode HR and Holstein TW (2000). Parameters of self-organization in Hydra aggregates. Proc Natl Acad Sci. 97:12127-31.

 

Miller M, Technau U, Smith KM and Steele R (2000). Oocyte development in Hydra involves selection from competent precursor cells. Dev Biol. 224:326-338.

 

1999

Technau U and Bode HR (1999). HyBra1, a Brachyury homologue, acts during head formation in Hydra. Development 126:999-1010.