The Department

How complex animal body plans could arise in evolution is one of the fundamental questions in biology. We address this question by investigating the underlying genomic, molecular and developmental processes that led to the diversification of animal body plans. We use cnidarians (jellyfish, corals and anemones) as model organisms to understand the evolution of key bilaterian features: bilaterality, central nervous systems and three germ layers.  Read more

Comparative and experimental genomics of birds and flies is used to reveal the mechanisms leading to the evolution and differentiation of sex chromosomes.  Read more

Head of Department



Prof. Ulrich Technau

Our model organisms to study the evolution of fundamental body plan features are the Cnidaria (sea anemones, corals, jellyfish, hydras), which are considered to be the sister group of the Bilateria. The Cnidaria are thought to have arisen some 600 Mio years ago. They display one apparent body axis (oral-aboral), and consist of only two cell layers, called ectoderm and endoderm. They have a diffuse nervous system. 

Hence, the question is, how this major transition from a diploblastic, radially symmetric animal such as the Cnidaria occurred to evolve the triploblastic bilaterally symmetric animals. (Read more)

Dr. Grigory Genikhovich, Group Leader and Vice Head of Department



Genikhovich Group

I am interested in understanding how molecular mechanisms regulating animal body axes evolved. To find this out, I am using an excellent experimental model, the sea anemone Nematostella vectensis. It belongs to Cnidaria, a phylum consisting of morphologically simply organized diploblastic organisms, which occupies a crucial phylogenetic position as a sister group to all Bilateria (triploblastic animals with anterior-posterior and dorsal-ventral body axes).  Intriguingly, true bilaterality exists also outside Bilateria, and Nematostella is one of such non-bilaterian bilaterally symmetric animals. (Read more)

Prof. Qi Zhou, Group Leader



Zhou Group

In many Drosophila species, autosomes have fused to the ancestral sex chromosome pair very recently which then evolve exactly like sex chromosomes. These particular so-called ’neo-sex’ systems are unique models to study fundamental questions like how X and Y chromosomes change their sequence feature and expression level during their divergence from each other, how are the processes dictated by chromosome-wide epigenetic regulatory changes, how dosage compensation evolves etc. These questions are usually very difficult to address in the classic model systems like human and Drosophila melanogaster, whose sex chromosomes are too old to study. (Read more)

Prof. Oleg Simakov, Group Leader



Simakov Group

We study major transitions in metazoan evolution from the perspective of the underlying genomic changes. Over the past years, we have contributed to the broader sampling of metazoan genomes, revealing ancestral metazoan and bilaterian genomic architectures and their diversification patterns. While we can trace back many gene families to the ancient metazoan ancestor, we also find many of them linked at both micro- (local gene cluster) and macro-syntenic (chromosomal) levels. The functional significance of most of those linkages during development is unknown. Having a broad phylogenetic focus we aim to (1) characterize and expand our knowledge of conserved and novel gene linkages and their associated (non-coding) elements across metazoans, (2) study their evolutionary dynamics through comparative genomics and modeling approaches, and (3) establishing molecular tools for investigating their role during development and clade-specific innovation. (Read more)

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PNAS paper for Oleg Simakov, Hannah Schmidbaur and co-authors!


Prof. Technau part of an article in the Kronenzeitung


Uni:docs fellowship for Luohao Xu!


COSB Colloquium Scedule!


Ekaterina Pukhlyakova published a paper in PNAS about β-catenin mechanotransduction


Rohit Dnyansagar wrote a paper about cnidarian relationships across the Atlantic

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